๐”– Bobbio Scriptorium
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Cell aggregation: Properties of cell surface factors from five species of sponge

โœ Scribed by McClay, David R.

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
959 KB
Volume
188
Category
Article
ISSN
0022-104X

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โœฆ Synopsis

Abstract

Aggregation factors isolated from the cell surface of five species of sponge are shown to be specific in their ability to enhance cell aggregation. Factors from Haliclona viridis, Haliclona variabilis, Tedania ignis, Homaxinella rudis, and Dysidea crawshayi each exhibit the species specific enhancing effect and have no such effect in heterospecific cellโ€factor combinations. Radioactively labeled cell free supernatant materials are shown to bind selectively to homospecific cells suggesting that cells contain specific receptors for attachment of the aggregation mediating materials. Finally, in several heterospecific combinations there was an inhibition of cell aggregation. The inhibitory agent was separated from the enhancing factor chromatographically. After removal of the inhibitory substance, the enhancing factor was still active in promoting cell aggregation of the homospecific cells only.

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