Ceftazidime and amikacin as empiric treatment of febrile episodes in neutropenic patients in Saudi Arabia
β Scribed by C.R. Santhosh-Kumar; D.S.S. Ajarim; M.S. Harakati; A.K. Al Momen; F. Al Mohareb; R.G. Zeitany
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 532 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0163-4453
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One hundred and seventy-one consecutive febrile episodes occurring in 130 neutropenic adult patients with hematological malignancies (mainly acute leukemia) were empirically treated with a combination antibiotic therapy consisting of ceftazidime (100 mg/kg/day) + amikacin (1 5 mg/kg/day). Of these,
## Abstract Amikacin (600 mg/m^2^/day IV) and ticarcillin (12 gm/m^2^/day IV) were administered to 38 children with cancer, neutropenia (< 1,000 PMN/mm^3^), and fever (β₯ 38Β°C) during 46 febrile episodes. Sixtyβone percent of the children were severely neutropenic (<200 PMN/mm^3^). Febrile episodes
This study aimed to evaluate the efficacy of amikacine and ceftazidime as an empirical antibiotic therapy for neutropenic patients affected by haematological neoplasms and to investigate the presence of prognostic features suggesting a poor outcome with this antibiotic combination at the onset of in