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Cefotaxime plus amikacin as empiric therapy in the treatment of febrile episodes in neutropenic patients with hematologic malignancies

✍ Scribed by P. Martino; M. Venditti; P. Serra; M. C. Petti; F. Mandelli


Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
699 KB
Volume
13
Category
Article
ISSN
0300-8126

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One hundred and seventy-one consecutive febrile episodes occurring in 130 neutropenic adult patients with hematological malignancies (mainly acute leukemia) were empirically treated with a combination antibiotic therapy consisting of ceftazidime (100 mg/kg/day) + amikacin (1 5 mg/kg/day). Of these,

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## Abstract Amikacin (600 mg/m^2^/day IV) and ticarcillin (12 gm/m^2^/day IV) were administered to 38 children with cancer, neutropenia (< 1,000 PMN/mm^3^), and fever (β‰₯ 38Β°C) during 46 febrile episodes. Sixty‐one percent of the children were severely neutropenic (<200 PMN/mm^3^). Febrile episodes