Cefotaxime plus amikacin as empiric therapy in the treatment of febrile episodes in neutropenic patients with hematologic malignancies
β Scribed by P. Martino; M. Venditti; P. Serra; M. C. Petti; F. Mandelli
- Publisher
- Springer-Verlag
- Year
- 1985
- Tongue
- English
- Weight
- 699 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0300-8126
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π SIMILAR VOLUMES
One hundred and seventy-one consecutive febrile episodes occurring in 130 neutropenic adult patients with hematological malignancies (mainly acute leukemia) were empirically treated with a combination antibiotic therapy consisting of ceftazidime (100 mg/kg/day) + amikacin (1 5 mg/kg/day). Of these,
## Abstract Amikacin (600 mg/m^2^/day IV) and ticarcillin (12 gm/m^2^/day IV) were administered to 38 children with cancer, neutropenia (< 1,000 PMN/mm^3^), and fever (β₯ 38Β°C) during 46 febrile episodes. Sixtyβone percent of the children were severely neutropenic (<200 PMN/mm^3^). Febrile episodes