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cDNA Cloning, Genomic Structure, and Chromosomal Localization of a Novel Murine Epidermis-type Lipoxygenase

✍ Scribed by Andreas Kinzig; Markus Heidt; Gerhard Fürstenberger; Friedrich Marks; Peter Krieg

Book ID
115614746
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
153 KB
Volume
58
Category
Article
ISSN
0888-7543

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Null mutations in the glucokinase (GCK) gene can cause autosomal dominant type 2 diabetes (maturity onset diabetes of the young, MODY); however, MODY is genetically heterogeneous. In both liver and pancreatic islet, glucokinase is subject to inhibition by a regulatory protein (GCKR). Given the role