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cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant

✍ Scribed by Da-Hong Wang; Ken Tsutsui; Kuniaki Sano; Noriyoshi Masuoka; Shohei Kira


Book ID
114147435
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
255 KB
Volume
1522
Category
Article
ISSN
0167-4781

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Calpains are calcium-activated cysteine proteases that are involved in cellular degradation in models of neurodegeneration. Calpains are the effectors of cytoskeletal disruption during axonal degeneration, a pathological feature of many neurological disorders. The WLD S mouse mutant is resistant to