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CDKN2A region polymorphism and genetic susceptibility to melanoma in the melim swine model of familial melanoma

✍ Scribed by Catherine Le Chalony; Christine Renard; Silvia Vincent-Naulleau; Françoise Crechet; Jean-Jacques Leplat; Yves Tricaud; Vratislav Horak; Joseph Gruand; Pascale Le Roy; Gérard Frelat; Claudine Geffrotin

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
87 KB
Volume
103
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Some herds of miniature swine are genetically predisposed to cutaneous melanoma. To test if swine melanoma susceptibility could be linked to the CDKN2A gene, which is involved in a proportion of 9p21‐linked human familial melanoma, we performed a genetic analysis of miniature pigs of the MeLiM strain. F~1~ and backcross animals were generated by crossing 1 MeLiM boar with healthy Duroc sows. We isolated the swine CDKN2A gene and characterized a linked informative microsatellite marker, the S0644 marker. Using this marker and 2 flanking markers, we analyzed the segregation of the CDKN2A gene in a 3‐generation pedigree. Allelic association, linkage analysis and haplotype analysis of these data led to exclusion of the CDKN2A gene as a candidate for melanoma susceptibility. Nonetheless, this analysis suggests an association with the swine 1q25 chromosomal region, which is homologous to the human 9p21 region. © 2002 Wiley‐Liss, Inc.

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