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CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

✍ Scribed by Firestein, Ron; Bass, Adam J.; Kim, So Young; Dunn, Ian F.; Silver, Serena J.; Guney, Isil; Freed, Ellen; Ligon, Azra H.; Vena, Natalie; Ogino, Shuji

Book ID
109897600
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
769 KB
Volume
455
Category
Article
ISSN
0028-0836

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CDK8 expression in 470 colorectal cancer
CDK8 expression in 470 colorectal cancers in relation to β-catenin activation, other molecular alterations and patient survival
✍ Ron Firestein; Kaori Shima; Katsuhiko Nosho; Natsumi Irahara; Yoshifumi Baba; Em 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 391 KB

## Abstract Alterations in the Wnt/β‐catenin pathway define a key event in the pathogenesis of colon cancer. We have recently shown that __CDK8__, the gene encoding a cyclin‐dependent kinase (CDK) component of the Mediator complex, acts as a colon cancer oncogene that is necessary for β‐catenin act