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CDX2 is mutated in a colorectal cancer with normal APC/β-catenin signaling

✍ Scribed by da Costa, Luis T; He, Tong-Chuan; Yu, Jian; Sparks, Andrew B; Morin, Patrice J; Polyak, Kornelia; Laken, Steve; Vogelstein, Bert; Kinzler, Kenneth W

Book ID: 110062281
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 328 KB
Volume: 18
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1202872

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## Abstract ## BACKGROUND: Abnormal activation of the Wnt/β‐catenin signaling pathway is common and critical in the pathogenesis of digestive cancers. In this study, the authors investigated the promoter methylation of the dickkopf homolog 3 gene __Dkk‐3__ in these cancers and its prognostic signi