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CDK2 and cyclin E knockout mice: lessons from breast cancer

✍ Scribed by Nathan H Lents; Joseph J Baldassare

Book ID
116908774
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
152 KB
Volume
15
Category
Article
ISSN
1043-2760

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Cyclins and their associated kinases (cdks) play a key role in controlling the cell cycle, a process whose disregulation can potentially lead to uncontrolled cell growth and hence to cancer. We have studied the role of both cyclin E and its associated kinase cdk2 in ovarian cancer. Primary, metastat