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Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27Kip1 in the cyclin E–cdk2 complexes

✍ Scribed by Nahum, Amit; Hirsch, Keren; Danilenko, Michael; Watts, Colin KW; Prall, Owen WJ; Levy, Joseph; Sharoni, Yoav


Book ID
110064728
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
288 KB
Volume
20
Category
Article
ISSN
0950-9232

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In the present study, TP53 alterations have been analysed and compared with the expression of the proteins p21, cyclin D1, cdk4, RB, EGFR, and MDM2 in 53 cancers of the uterine corpus. TP53 gene mutations analysed by CDGE/DGGE and direct sequencing showed a TP53 gene mutation in 18 per cent of the c