CDH1 −160C>A gene polymorphism is an ethnicity-dependent risk factor for gastric cancer
✍ Scribed by Feng Pan; Jing Tian; Ying Zhang; Yue-Yin Pan
- Book ID
- 116400651
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 145 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1043-4666
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## Abstract Part of the inherited susceptibility to colorectal cancer (CRC) is caused by the coinheritance of common low risk variants. E‐cadherin (__CDH1__) has an established role in CRC; somatic inactivation of __CDH1__ is a common early event, and germline mutations can cause early‐onset CRC. T
We have combined data from case control studies designed to test the hypothesis that the c-160a promotor polymorphism in the gene coding for the cell adhesion molecule E-cadherin (CDH1) is associated with stomach cancer. A total of 899 individuals (433 patients and 466 controls) were analyzed. The g