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CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer

✍ Scribed by Paul D.P. Pharoah; Carla Oliveira; José Carlos Machado; Gisella Keller; Holger Vogelsang; Holger Laux; Karl-Friedrich Becker; Heidi Hahn; Suzanne M. Paproski; Lindsay A. Brown; Carlos Caldas; David Huntsman

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
66 KB
Volume
101
Category
Article
ISSN
0020-7136

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✦ Synopsis

We have combined data from case control studies designed to test the hypothesis that the c-160a promotor polymorphism in the gene coding for the cell adhesion molecule E-cadherin (CDH1) is associated with stomach cancer. A total of 899 individuals (433 patients and 466 controls) were analyzed. The genotype frequencies did not differ significantly between cases and controls, and the genotype-specific risks were not significantly different from unity, with an odds ratio for heterozygotes compared with the common homozygote of 1.3 (95% CI 0.98-1.8) and 1.2 (0.68-2.0) for rare homozygotes compared with common homozygotes. We found no evidence for differences in risk for the intestinal- and diffuse-type histopathologic subgroups.

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