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Cdc2-Independent Induction of Premature Mitosis by Okadaic Acid in HeLa Cells

โœ Scribed by S. Ghosh; N. Paweletz; D. Schroeter

Book ID
115603006
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
259 KB
Volume
242
Category
Article
ISSN
0014-4827

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๐Ÿ“œ SIMILAR VOLUMES

Failure of centromere separation leads t
Failure of centromere separation leads to formation of diplochromosomes in next mitosis in okadaic acid treated HeLa cells.
โœ Sibdas Ghosh; Neidhard Paweletz; Dieter Schroeter ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 260 KB

## Abstract High concentrations of okadaic acid, sufficient to inhibit phosphatase 1 and 2A activities, induces formation of diplochromosomes in HeLa cells. It has been shown that this is due to a failure of sister chromatid separation in earlier mitosis in the presence of okadaic acid in the mediu

Selective induction of cell cycle regula
Selective induction of cell cycle regulatory genes cdk1 (p34cdc2), cyclins a/b, and the tumor suppressor gene RB in transformed cells by okadaic acid
โœ Jinsong You; R. Curtis Bird ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 962 KB

Genes encoding cdkl (~34'~''), cyclin A, cyclin B, and the tumor suppressor gene Rb are fundamental regulators of cell cycle progression which associate as a complex with the transcription factor E2F. Expression of many of these proteins has previously been shown to be repressed by okadaic acid, a s