CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'
β Scribed by Perchellet, Antoine; Stromnes, Ingunn; Pang, Jennifer M; Goverman, Joan
- Book ID
- 109921867
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 657 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1529-2908
- DOI
- 10.1038/ni1073
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π SIMILAR VOLUMES
Encephalitogenic T cells from Lewis rats use a restricted T cell receptor (TCR) gene combination, Vbeta8.2 and Valpha2. The oral administration of myelin basic protein (MBP) to Lewis rats prior to encephalitogenic challenge results in a marked inhibition of clinical neurologic signs of encephalitis,
Several recently discovered lines of evidence support the involvement of my elin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested