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T and B cell responses to myelin basic protein and encephalitogenic epitopes

✍ Scribed by Karen E. Gould; Robert H. Swanborg


Book ID
119108626
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
526 KB
Volume
46
Category
Article
ISSN
0165-5728

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T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence

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The epitope specificities of myelin basic protein (BP) specific T cell lines derived from the spinal cords (SC) and lymph nodes (LN) of rats with experimental autoimmune encephalomyelitis (EAE) were compared. To induce EAE, Lewis rats were immunized with guinea pig (GP)-BP and complete Freund's adju