CD8 and β2-microglobulin-free MHC class I molecules in T cell immunoregulationMHC class I molecules in T cell immunoregulation
✍ Scribed by Sandra Demaria; Yuri Bushkin
- Book ID
- 110573238
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 992 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0940-5437
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Tcrb-V-specific positive and negative selection of T cells has been well documented. In contrast, nothing is known about Tcra-V-specific selection. Using Tcra-V8-specific KT50 antibody Tcra-V8-specific selection of T cells has been examined. The CD8+ T cell subpopulation bearing Tcra-V8 are shown to
## Increased number of cytotoxic T cells within CD4+8-T cells in P2-microglobulin, major histocompatibility complex class I-deficient mice* Targeted disruption of fi2-microgobulin gene results in deficient major histocompatibility complex class I expression and failure to develop CD4-V T cells. De