CD44 variant expression and estrogen receptor status in breast cancer
โ Scribed by A. Kate Hole; Abbes Belkhiri; Linda S. Snell; Peter H. Watson
- Book ID
- 110229312
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 81 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0167-6806
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๐ SIMILAR VOLUMES
CD44 is a family of cell surface transmembrane glycoproteins members which differ in the extracellular part by sequences derived by alternative splicing of 10 variant exons (v1-v10). CD44 proteins containing such variant sequences have been implicated in tumor metastasis formation. Here, we have eva
The local expression of CD44 splice variants in human breast cancer tissue has been previously shown to be associated with metastasis. We show here that elevated systemic serum levels of CD44 splice variants occur in breast cancer and may represent a new tool for staging and differential diagnosis.