CD40 Mediates Downregulation of CD32B on Specific Memory B Cell Populations in Rheumatoid Arthritis
β Scribed by Zhang, X.; Burch, E.; Cai, L.; So, E.; Hubbard, F.; Matteson, E. L.; Strome, S. E.
- Book ID
- 121417114
- Publisher
- American Association of Immunologists
- Year
- 2013
- Tongue
- English
- Weight
- 950 KB
- Volume
- 190
- Category
- Article
- ISSN
- 0022-1767
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Circulating CD5+ B-cell levels in 15 patients with rheumatoid arthritis (RA) not receiving remittive therapy was significantly increased when compared to 17 normal controls (mean +/- SE: RA, 19.7 +/- 2.85%; controls, 11.6 +/- 1.67%; P less than 0.02). In contrast, 24 patients with RA receiving gold
Objective. B lymphocytes accumulate in the inflamed joints of patients with rheumatoid arthritis (RA) and are responsible for production of high amounts of (auto)-antibodies. The aim of this study was to determine the capacity of fibroblast-like synoviocytes (FLS) to contribute to the accumulation o