CD4+ T helper 2 cells – microbial triggers, differentiation requirements and effector functions
✍ Scribed by Isobel S. Okoye; Mark S. Wilson
- Book ID
- 108782949
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 303 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0019-2805
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## Abstract Notch1 proteins are involved in binary cell fate decisions. To determine the role of Notch1 in the differentiation of CD4^+^ Th1 versus Th2 cells, we have compared T helper polarization __in vitro__ in naive CD4^+^ T cells isolated from mice in which the N1 gene is specifically inactiva
Allergen-specific T cells from atopic patients generally belong to the T-helper type 2 subset. IL-4 and IL-13 produced by these cells induce IgE synthesis by B cells and play a major role in allergic disease mediated by IgE. Recent advances in our understanding of the differentiation and IgE-inducin