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CD4+ T cells inhibit the neu-specific CD8+ T-cell exhaustion during the priming phase of immune responses against breast cancer

✍ Scribed by Maciej Kmieciak; Andrea Worschech; Hooman Nikizad; Madhu Gowda; Mehran Habibi; Amy Depcrynski; Ena Wang; Kamar Godder; Shawn E. Holt; Francesco M. Marincola; Masoud H. Manjili

Publisher
Springer US
Year
2010
Tongue
English
Weight
585 KB
Volume
126
Category
Article
ISSN
0167-6806

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## Abstract Spontaneous tumors frequently express antigens that can be recognized by the immune system but nevertheless manage to evade immune surveillance. To better understand the mechanism of evasion, we followed CD8 and CD4 T cells reacting against a subcutaneously growing tumor, modified to ex