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CD4+ murine T cells develop from CD8+ precursors in vivo

โœ Scribed by Smith, Laurie

Book ID
109749178
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
329 KB
Volume
326
Category
Article
ISSN
0028-0836

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A differentiation pathway from CD4+CD8+ cells to CD4+CD8- or CD4-CD8+ cells was investigated in athymic nude mice. Using fluorescence-activated cell sorter, CD4+CD8+ cells were sorted out from AKR thymocytes (H-2k, Thy-1.1) stained with two monoclonal antibodies against CD4 and CD8 (anti-L3T4 and an