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CD4+ CD25+ regulatory T cells in human pregnancy: development of a Treg-MLC-ELISPOT suppression assay and indications of paternal specific Tregs

✍ Scribed by Jenny Mjösberg; Göran Berg; Jan Ernerudh; Christina Ekerfelt


Book ID
108782022
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
708 KB
Volume
120
Category
Article
ISSN
0019-2805

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## Abstract The aim of this study was to investigate whether depletion of CD4^+^CD25^+^ regulatory T cells (Treg) from melanoma patients affects immune responses against tumors. By application of recombinant IL‐2‐diphteria toxin fusion protein, also known as ONTAK, we were able to significantly red