✦ LIBER ✦

CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?

✍ Scribed by Rose Zamoyska

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 663 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80036-8

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✦ Synopsis

CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses? Rose Zamoyska

The response of T cells to antigen involves the participation of a number of distinct receptor-ligand engagements. The major players in the recognition of complexes of major histocompatibility complex molecules and peptide antigens are the T-cell receptors and the co-receptors CD4 and CDS. Progress in understanding the physical structures of these molecules, and how complexes between them are formed, is helping our understanding of how they participate in regulating the signals transduced to T cells.

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