𝔖 Bobbio Scriptorium
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CD38 expression on cryopreserved CD8+ T cells predicts HIV disease progression

✍ Scribed by Stephen P. Perfetto; John D. Malone; Clifton Hawkes; Gilbert McCrary; Bob August; Susan Zhou; Robin Garner; Matthew J. Dolan; Arthur E. Brown

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
140 KB
Volume
33
Category
Article
ISSN
0196-4763

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✦ Synopsis

Previous studies have revealed that the expression of CD38 on CD8 Ο© T cells is a strong predictor of disease progression in human immunodeficiency virus (HIV)-infected individuals. Those studies were performed using fresh patient samples over an extended trial period. After demonstrating the validity of assay results on cryopreserved cells, we performed a retrospective study using frozen cell samples to determine the predictive value of CD38 expression in patients with CD4 counts above 400 cells/Β΅l. The CD38 expression as measured by antibody binding capacity and the CD38 median channel were shown to be associated with time to new opportunistic infection or death (both P F 0.001). These results suggest that CD38 expression on CD8 Ο© T cells, whether fresh or frozen, provides a useful predictor of HIV disease progression.

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