The role of CD22 and other inhibitory co
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Lars Nitschke
📂
Article
📅
2005
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Elsevier Science
🌐
English
⚖ 1012 KB
Inhibitory co-receptors downmodulate B-cell receptor (BCR) signalling by setting a signalling threshold that prevents overstimulation of B cells. Activation of these inhibitory co-receptors occurs by phosphorylation on their cytoplasmic inhibitory immunoreceptor tyrosine-based inhibition motifs (ITI