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CD20-positive adult T-cell leukemia

โœ Scribed by Masaki Yasukawa; Junko Arai; Miki Kakimoto; Ikuya Sakai; Hidehisa Kohno; Shigeru Fujita

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
45 KB
Volume
66
Category
Article
ISSN
0361-8609

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โœฆ Synopsis

A 67-year-old woman was admitted to our hospital because of lymphadenopathy and lymphocytosis. Monoclonal integration of HTLV-I provirus DNA was detected, and a diagnosis of adult T-cell leukemia (ATL) was made. Flow cytometry revealed that the ATL cells expressed CD20 as well as T-cell-associated antigens, and expression of CD20 mRNA was also demonstrated. A novel T-cell subpopulation expressing CD20 molecules has recently been identified. This is the first report of CD20-positive ATL, suggesting that HTLV-I can infect and transform CD20-positive T cells. Am.

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