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CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other human cancers

✍ Scribed by Yong-Jie Lu; Elodie E. Noel; Marc Yeste-Velasco; Xueying Mao; Jackie Perry; Sakunthala C. Kudahetti; Ningfeng F. Li; Tracy Chaplin; R. Tim D. Oliver; Janet Shipley; Daniel M. Berney; Simon P. Joel; Bryan D. Young


Book ID
113513852
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
42 KB
Volume
203
Category
Article
ISSN
0165-4608

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## Abstract Testicular germ‐cell tumors (TGCTs) show exquisite sensitivity to cisplatin‐based chemotherapy, and therefore this is considered a good model system for studying the mechanism of chemotherapy resistance. Although the genetic alterations related to TGCT have been well studied, little is