Causes of death in febrile granulocytopenic cancer patients receiving empiric antibiotic therapy
β Scribed by Sculier, J.P.; Weerts, D.; Klastersky, J.
- Book ID
- 122426347
- Publisher
- Elsevier Science
- Year
- 1984
- Weight
- 577 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0277-5379
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In a prospective, randomized trial, 205 febrile episodes in granulocytopenic cancer patients were treated with ceftazidime with or without tobramycin (C +/- T), both agents being administered only if the initial granulocyte count was below 200/microliters, or ceftazidime plus piperacillin (C + P). T
One hundred and seventy-one consecutive febrile episodes occurring in 130 neutropenic adult patients with hematological malignancies (mainly acute leukemia) were empirically treated with a combination antibiotic therapy consisting of ceftazidime (100 mg/kg/day) + amikacin (1 5 mg/kg/day). Of these,