𝔖 Bobbio Scriptorium
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Cathepsins and compartmentalization in antigen presentation

✍ Scribed by Richard J Riese; Harold A Chapman

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
93 KB
Volume
12
Category
Article
ISSN
0952-7915

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✦ Synopsis

Intracellular trafficking and cell surface expression of MHC class II molecules is a tightly regulated process and is to a large extent, determined by the fate of the class II chaperone, the invariant chain. Inhibition of endosomal proteases critical to invariant chain proteolysis reveals marked shunting of class II complexes to lysosomal compartments. Regulation of endosomal protease activity by expression of cystatin C directs class II cell surface expression during maturation of dendritic cells. These studies highlight the taut interactions between class-II-invariant-chain complexes and endosomal proteases during MHC class II maturation.

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✍ D.R. Katz πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 English βš– 812 KB

To summarize, during the period under review there have been considerable advances in our understanding of how antigen is associated with MHC on the surface of a presenting cell. Basic rules which govern this association have been confirmed as including both the nature and the configuration of the a