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Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells

✍ Scribed by Ulrik Hillaert; Martijn Verdoes; Bogdan I. Florea; Anastasios Saragliadis; Kim L. L. Habets; Johan Kuiper; Serge Van Calenbergh; Ferry Ossendorp; Gijsbert A. van der Marel; Christoph Driessen; Hermen S. Overkleeft

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
148 KB
Volume
121
Category
Article
ISSN
0044-8249

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## Abstract The unique therapeutic value of dendritic cells (DCs) for the treatment of allergy, autoimmunity and transplant rejection is predicated upon our ability to selectively deliver antigens, drugs or nucleic acids to DCs in vivo. Here we describe a method for delivering whole protein antigen