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Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function

✍ Scribed by M. Matsumoto; C.Shannon Weickert; M. Akil; B.K. Lipska; T.M. Hyde; M.M. Herman; J.E. Kleinman; D.R. Weinberger


Book ID
117490792
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
534 KB
Volume
116
Category
Article
ISSN
0306-4522

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## Abstract Catechol‐o‐methyltransferase (COMT) is important for modulating dopamine levels, prefrontal cortex (PFC) function, and several psychiatric phenotypes. A single COMT mRNA has been described in human brain, which gives rise to membrane‐bound (MB)‐ and soluble (S)‐COMT proteins. In additio