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Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond

โœ Scribed by Elizabeth M. Tunbridge; Paul J. Harrison; Daniel R. Weinberger

Book ID
119197043
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
407 KB
Volume
60
Category
Article
ISSN
0006-3223

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Catechol-O-methyltransferase val158met a
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โœ Jeroen Hoogland; Rob M.A. de Bie; Caroline H. Williams-Gray; Dino Muslimoviฤ‡; Be ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 64 KB

## Abstract Cognitive dysfunction is one of the most incapacitating nonโ€motor symptoms of Parkinson's disease (PD). Some cognitive deficits are thought to be related to abnormal dopamine homeostasis. The latter is influenced by catecholโ€Oโ€methyltransferase (COMT), an enzyme that degrades dopamine.