Catalytic hydrogenolysis in liquid ammonia: stability and cleavage of some protecting groups used in peptide synthesis
β Scribed by Johannes Meienhofer; Kenji Kuromizu
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- French
- Weight
- 224 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The value of several reagents capable of removing quantitatively the Ξ±βamino protecting group of NPSβaminoacylβ or peptidylβderivatives is assessed, by comparison with the reagents currently used, __i.e.__ hydrogen chloride, RS^β^βnucleophiles or alkyl thioamides, especially with regard
protected The allylic handle -0-CH2-CH-CH-CH2-0-CH2-CO-has been used in the synthesis of peptide fro ments on aminomethyl polystyrene. The palladium-catalyzed hydrostannolytic cleavage il of t e peptide fragments from the resin occurs under very mild conditions.