Catalytic enantioselective synthesis of macrolides via asymmetric alkylation

✍ Scribed by Graham B. Jones; Robert S. Huber; Brant J. Chapman

• Book ID: 104361203
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 874 KB
• Volume: 8
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(97)00186-9

✦ Synopsis

Catalytic enantioselective syntheses of the macrolides (R)-(-) phoracantholide and (R)-(+) lasiodiplodin have been achieved. Stereochemistry was introduced in using an arene chromium tricarbonyl derived catalyst, which mediated the enantioselective addition of dimethyl zinc to a functionalized aldehyde.