Catalytic Enantioselective Addition of Dialkylzinc to N -Diphenylphosphinoylimines. A Practical Synthesis of α-Chiral Amines
✍ Scribed by Boezio, Alessandro A.; Charette, André B.
- Book ID
- 120260079
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 57 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0002-7863
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The use of cinchona alkaloids to promote the addition of diethylzinc to P,P-diphenyl-N-(phenylmethylene)phosphinic amide has been examined. Using cinchonine and cinchonidine as ligands, the S and R enantiomers of N-(1-phenylpropyl)-P,Pdiphenylphosphinic amide were prepared in good yield with up to 9
Chiral dendrimers with three or six β-amino alcohols on hyperbranched hydrocarbon chain-ends were synthesized. These macromolecules can act as chiral catalysts for the enantioselective addition of dialkylzincs to aldehydes. The corresponding secondary alcohols are obtained in high enantiomeric exces