Catalytic asymmetric weitz-scheffer epoxidation promoted by bovine serum albumin. Part II

✍ Scribed by Stefano Colonna; Amedea Manfredi; Rita Annunziata; Massimo Spadoni

• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 455 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)86797-1

✦ Synopsis

The epoxidation of 2 and 2,3-substituted naphthoquinones with t-BuOOH In aqueous buffer solutions, in the presence of bovine serum albumin (BSA) as chiral catalyst, affords the corresponding epoxynaphthoquinones with enantiomeric excess (e.e.1 up to 79%. The influences on the enantioselectivity of the pH of the buffer solution, of the oxidizlng agent, and of inorganic salts have also been examined.