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Catalytic asymmetric synthesis with trans-chelating chiral diphosphine ligand TRAP: rhodium-catalyzed asymmetric Michael addition of .alpha.-cyano carboxylates

✍ Scribed by Sawamura, Masaya; Hamashima, Hitoshi; Ito, Yoshihiko


Book ID
127272319
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
288 KB
Volume
114
Category
Article
ISSN
0002-7863

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Catalytic asymmetric hydrogenation of 1-
✍ Ryoichi Kuwano; Daisuke Karube; Yoshihiko Ito πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 289 KB

A rhodium complex coordinated with a trans-chelating chiral diphosphine (S,S)-(R,R)-PhTRAP was an effective catalyst for asymmetric hydrogenation of N-acyl-1-aza-2-cycloalkene-2-carboxylates, which gave the corresponding protected cyclic or-amino acids with 73-97% ee.