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Catalytic asymmetric synthesis of axially chiral biaryls by palladium-catalyzed enantioposition-selective cross-coupling.

โœ Scribed by Hayashi, Tamio; Niizuma, Satoshi; Kamikawa, Takashi; Suzuki, Nobuhiro; Uozumi, Yasuhiro


Book ID
119945788
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
286 KB
Volume
117
Category
Article
ISSN
0002-7863

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Enantioposition-selective arylation of b
โœ Takashi Kamikawa; Tamio Hayashi ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 869 KB

Asymmetric cross-coupling of achiral biaryl ditriflates with aryl Grignard reagents in the presence of 1 equiv of lithium bromide and 5 tool % of palladium complex PdC12[(S)-alaphos], where alaphos stands for (2dimethylamino)propyldiphenylphosphine, gave axially chiral monophenylation products with