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Catalytic Asymmetric Reaction with Water: Enantioselective Synthesis of α-Hydroxyesters by a Copper–Carbenoid OH Insertion Reaction

✍ Scribed by Shou-Fei Zhu; Chao Chen; Yan Cai; Qi-Lin Zhou


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
299 KB
Volume
120
Category
Article
ISSN
0044-8249

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## Abstract Using the __C__~2~‐symmetric bis‐oxazoline copper(II) catalyst **6f** as a chiral Lewis acid, α′‐phosphoric enones **2** undergo 1,3‐dipolar cycloaddition with nitrones **3** to provide isoxazolidines **4** with very high enantioselectivity and __endo/exo__ selectivity.