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Catalytic Asymmetric Propionate Aldol Reactions via Acyl Halide−Aldehyde Cyclocondensations

✍ Scribed by Nelson, Scott G.; Wan, Zhonghui


Book ID
118216635
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
124 KB
Volume
2
Category
Article
ISSN
1523-7060

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Catalyzed acyl halidealdehyde cyclocond
✍ Scott G. Nelson; Zhonghui Wan; Timothy J. Peelen; Keith L. Spencer 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 295 KB

Substoichiometric quantities (2.5-20 tool%) of AI(SbF6)3 catalyze the di(isopropyl)ethylamine-mediated cyclocondensation of various acyl halides and enolizable aldehydes to afford I$-lactones in good yields (58-93%). These reactions are discussed as a strategy for executing chemo-and regiospecific c