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Catalytic Asymmetric Acyl Halide−Aldehyde Cyclocondensations. A Strategy for Enantioselective Catalyzed Cross Aldol Reactions

✍ Scribed by Nelson, Scott G.; Peelen, Timothy J.; Wan, Zhonghui

Book ID
126275172
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
40 KB
Volume
121
Category
Article
ISSN
0002-7863

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Catalyzed acyl halidealdehyde cyclocond
Catalyzed acyl halidealdehyde cyclocondensations. New insights into the design of catalytic cross aldol reactions
✍ Scott G. Nelson; Zhonghui Wan; Timothy J. Peelen; Keith L. Spencer 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 295 KB

Substoichiometric quantities (2.5-20 tool%) of AI(SbF6)3 catalyze the di(isopropyl)ethylamine-mediated cyclocondensation of various acyl halides and enolizable aldehydes to afford I$-lactones in good yields (58-93%). These reactions are discussed as a strategy for executing chemo-and regiospecific c