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Catalytic asymmetric nitroaldol (Henry) reactions with copper(II)/cyclopropane-based bisoxazoline complexes

โœ Scribed by Jianyou Mao; Xin Nie; Min Wang; Qian Wang; Bing Zheng; Qinghua Bian; Jiangchun Zhong


Book ID
119375859
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
592 KB
Volume
23
Category
Article
ISSN
0957-4166

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## Abstract Using the __C__~2~โ€symmetric bisโ€oxazoline copper(II) catalyst **6f** as a chiral Lewis acid, ฮฑโ€ฒโ€phosphoric enones **2** undergo 1,3โ€dipolar cycloaddition with nitrones **3** to provide isoxazolidines **4** with very high enantioselectivity and __endo/exo__ selectivity.