Catalytic Asymmetric Direct Henry Reacti
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Dr. Daisuke Uraguchi; Shinji Nakamura; Prof. Dr. Takashi Ooi
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Article
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2010
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John Wiley and Sons
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English
⚖ 455 KB
silica gel (n-hexane/ethyl acetate = 4:1) afforded 4 a in quantitative yield. Enantiomeric excess of the anti isomer was determined to be 98 % ee by HPLC on a chiral stationary phase (Daisel Chiralpak AD-H, n-hexane/2-propanol/EtOH = 90:4.5:5.5, flow rate 1.0 mL min À1 ).