Catalytic asymmetric and chemoselective aerobic oxidation: kinetic resolution of sec-alcohols

✍ Scribed by Kouta Masutani; Tatsuya Uchida; Ryo Irie; Tsutomu Katsuki

• Book ID: 104210480
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 209 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00787-5

✦ Synopsis

Optically active (nitroso)(salen)ruthenium(II) chloride (2) was found to be an ecient catalyst for aerobic oxidation of racemic secondary alcohols under irradiation with a halogen or ¯uorescent lamp, which proceeded with good enantiomer-dierentiation (k rel =11±20). Furthermore, no epoxidation was observed in the oxidation of racemic 4-phenyl-3-buten-2-ol.