Catalytic Asymmetric Allylation of Aldehydes Using a Chiral Silver(I) Complex
β Scribed by Yanagisawa, Akira; Nakashima, Hiroshi; Ishiba, Atsushi; Yamamoto, Hisashi
- Book ID
- 120712037
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 102 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0002-7863
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The asymmetric cotalytic cyanosilylationof oliphaticaldehydes with Me3SiCN using (R)-BINOL-Ti(O-i-Pr)2 m an arymmem"c precakdyst is shown to proceed smoothly in dichloromethane to ~ford the cyanohydrinsin rekdvely high enantiose!ectivity (up @ 75~oee). @1997 Elsevier ScienceLtd. Recently,much inter
The complex generated from BINOL, Zr(O t Bu) 4 , and 4 A , MS in toluene-pivalonitrile is very effective for catalytic asymmetric allylation of aldehydes using allyltributyltin. The reactions of achiral aldehyde under these conditions are completed within 3 h using 10-20 mol% of the complex at -20Β°C
A new, chiral bidentate Ti(IV) complex of type 1 was successfully designed and can be utilized for simultaneous coordination to aldehyde carbonyls, thereby allowing the precise enantioface discrimination of such carbonyls for a new catalytic, practical enantioselective allylation of aldehydes with a