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Catalysis by Imidazole of Deuterium-Hydrogen Exchange in Amide N-H Groups

✍ Scribed by Klotz, I. M.; Frank, B. H.

Book ID
121169083
Publisher
American Association for the Advancement of Science
Year
1962
Tongue
English
Weight
549 KB
Volume
138
Category
Article
ISSN
0036-8075

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## Abstract Multi‐deuterium incorporations into drugs, such as theophylline, caffeine, valpromide, phenytoin, and trimethoprim, were post‐synthetically achieved by Pd/C‐, Pt/C‐, or/and Rh/C‐catalyzed hydrogen–deuterium exchange reactions under neutral conditions using deuterium oxide as the deuteri