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Catalysis of aromatic hydrogen-deuterium exchange by metal hydrides

✍ Scribed by Barefield, E. Kent.; Parshall, G. W.; Tebbe, F. N.

Book ID
126783798
Publisher
American Chemical Society
Year
1970
Tongue
English
Weight
244 KB
Volume
92
Category
Article
ISSN
0002-7863

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✍ Nkaelang Modutlwa; Tomohiro Maegawa; Yasunari Monguchi; Hironao Sajiki 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 157 KB

## Abstract Multi‐deuterium incorporations into drugs, such as theophylline, caffeine, valpromide, phenytoin, and trimethoprim, were post‐synthetically achieved by Pd/C‐, Pt/C‐, or/and Rh/C‐catalyzed hydrogen–deuterium exchange reactions under neutral conditions using deuterium oxide as the deuteri