Scheme 1. Retrosynthetic analysis of latrunculin B. Scheme 2. Synthesis of two building blocks by iron-catalyzed crosscoupling reactions: a) KHMDS, PhN(Tf) 2 , THF, ร 78 8C, 61 %; b) [Fe(acac) 3 ] (10 mol %), THF, ร 30 8C, 97 %; c) aqueous NaOH, MeOH, 92 %; d) CDI, THF, 71 %; e) NaH, PMBBr, THF, 77
โฆ LIBER โฆ
Catalysis-Based Total Synthesis of Latrunculin B.
โ Scribed by Alois Fuerstner; Dominic De Souza; Liliana Parra-Rapado; Jon T. Jensen
- Book ID
- 101951114
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 57 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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