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Catalepsy induced by calcium channel blockers in mice

✍ Scribed by Karoi Haraguchi; Kiyomi Ito; Hajime Kotaki; Yasfumi Sawada; Tatsuji Iga

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
198 KB
Volume
19
Category
Article
ISSN
0142-2782

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✦ Synopsis

It is known that calcium channel blockers induce Parkinsonism. In this study, amlodipine-, diltiazem-, and verapamil-induced catalepsy was investigated in mice. All of these three calcium channel blockers induced catalepsy. Dopamine D 1 , D 2 , and mACh receptor occupancies were estimated under the same conditions, and the affinities of these drugs for each receptor were also estimated in vitro. Intensity of catalepsy was predicted by dopamine D 1 , D 2 , and mACh receptor occupancies with the dynamic model which had already been constructed and was compared with the observed values. The predicted and the observed values were comparable (r=0.98, pB 0.001). In conclusion, the dynamic model considering D 1 , and D 2 , and mACh receptor occupancy may be useful for quantitative prediction of drug-induced catalepsy.

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