𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Confounding by indication: the case of calcium channel blockers

✍ Scribed by Marshall M. Joffe

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
83 KB
Volume
9
Category
Article
ISSN
1053-8569

No coin nor oath required. For personal study only.

✦ Synopsis

Purpose:

To review conceptual issues regarding confounding by indication in the context of studies of calcium channel blockers (ccbs).

Methods:

Review of literature, with special attention to two articles in the current issue.

Results:

Conflicting arguments about the presence of uncontrollable confounding by indication in studies of ccbs are reviewed and criticized. studies with potential confounding by indication can benefit from appropriate analytic methods, including separating the effects of a drug taken at different times, sensitivity analysis for unmeasured confounders, and instrumental variables and g-estimation.

Conclusions:

Whether confounding by indication accounts for observed associations is often difficult to determine; this is the case in studies of ccbs. when confounding by indication is suspected, a variety of methods to deal with it may be useful. copyright (c) 2000 john wiley & sons, ltd.

πŸ“œ SIMILAR VOLUMES

Calcium channel blockers in the treatmen
Calcium channel blockers in the treatment of disease
✍ Keith S. Elmslie πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 101 KB πŸ‘ 1 views

## Abstract Over the last 20 years the combination of patch clamp and molecular biology techniques have resulted in an explosion in our knowledge of the different calcium channel types and their roles in physiology. A crucial component to this advance has been the discovery of specific blockers for

Preparation and Characterization of Biot
Preparation and Characterization of Biotinylated Analogs of the Calcium Channel Blocker Ο‰-Conotoxin
✍ O.T. Jones; A.P. So πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 486 KB

We have prepared a series of biotinylated analogs of \(\omega\)-conotoxin ( \(\omega \mathrm{CgTx}\) ) as potent, selective markers for \(\mathrm{N}-\) type calcium channels. At \(\mathbf{p H} 9.5\), reaction of \(\omega \mathrm{CgTx}\) with amidocaproylbiotin succinimidyl ester gives three biotinyl